一、多肽药研发的技术瓶颈多肽合成的困难程度从中国牛胰岛素的合成。胰岛素由A、B两条肽链，共17种51个氨基酸组成。人工合成胰岛素，首先要把氨基酸按照一定的顺序连结起来，组成A链、B链，然后再把A、B两条链连在一起。由于当时还没出现固相合成的技术。显然这*是一项复杂艰巨的的工作。从1958年开始，经过6年多坚持不懈的努力和无数次失败经验的总结，终于在1965年9月17日，中国在世界上用人工方法合成了结晶牛胰岛素。当时中科院向诺贝尔奖评审委有关机构递交了相关资料和文件，但是由于这...

Thedifficultiesinvolvedinscalingupreactionsfromlaboratorytoprocessscalearewellknown,especiallywhendangerousmaterialsareinvolved.ThispaperwilldemonstratethecapabilityoftheH-CubeMidi™tosuccessfullyscale-uphydrogenationreactions.Reaction...

ThisapplicationnotewilldemonstratetheH-CubePro™’sincreasedproductivityinthehydrogenationofD-glucosetoD-sorbitol,whichisbelievedtobeakeyintermediateinbiofuelproduction.Hydrogenisgeneratedinsituthroughelectrolysisofwater.Boththeuseofele...

Thepharmaceuticalindustryiscontinuallysearchingtoautomatetechniquesforrapidoptimizationorlibraryproduction.Theautomationofhydrogenationisoneofthoseprocessesthatisdrawinghighinterestduetoitsfrequencyindrugsynthesis.OfficialThalesNanowebsite:...

ThehydrogenationofaseriesoffunctionalgroupshasbeenperformedusingH-Cube®,anovelcontinuous-flowmicrofluidichydrogenationreactor.TheseexperimentsdemonstratethattheH-Cube®canperformadiverserangeofheterogeneoushydrogenationreactionswithh...

INTRODUCTIONSelectivecatalytichydrogenationofa-b-unsaturatedaldehydesisanimportantstepintheindustrialpreparationoffinechemicalsａndattractsmuchinterestforfundamentalresearchincatalysis1.Cinnamylalcoholplaysanimportantroleintheperfumeａndflavo...